Ruby Nelle Crews Smith, 91, of Florence, SC, passed away on Tuesday, December 21, 2016, at the McLeod Hospice House. She was born in Oxford, NC, a daughter of the late Roy Walter and Ruby Adcock Crews. She is also preceded in death by her husband, William Clyde "Smitty" Smith, Jr.; a brother, Dr. Charles Crews, MD; and a sister, Margie Crawford; and a son-in-law, O.B. Grice, Jr. Nelle was a registered nurse and worked as head nurse of the ICU at Baptist Hospital. She started the Coronary Care Unit at Providence Hospital as well as the LPN Nursing Program at Midlands Technical College. She was a member of First Baptist church in Columbia and has attended the Florence Baptist Temple since moving to Florence. She is survived by two sons, W.C. "Rick" (Kathy) Smith, III of Edisto Beach and Roy (Karen) Smith of Columbia; daughter, Merrinelle S. Grice of Florence; six grandchildren, John (Hanna) Estill, William Clyde (Lauren) Smith, IV, Jared Dubose (Ashley) Smith, Annelle (Zach) Grice Blackwell, Katherine "Katie" Smith and Odell "Dell" (Casey) Beach Grice III; eight great-grandchildren, Claire Kesilyn Blackwell, Jake Estill, Hamp Estill, Charlotte Smith, Elizabeth Smith, Emma Smith, Brenyn Grice and Sawyer Grice; and a brother, Roy W. Crews, Jr. of Oxford, NC. A memorial service will be held at 11:00 AM on Saturday, January 7, 2017, in the Florence Baptist Temple Chapel. The family will receive friends at the church immediately following the service. Memorials may be made to the McLeod Hospital NICU, Timrod Elementary or to the SC Special Olympics.